Tenascins-R,oligodendrocyte-myelin glycoprotein(OMgp) located in nodal region and Nogo-A located in paranodal region are neurite growth inhibitors(NGI) associated with the Node of Ranvier(NORs).
APP成分肽的释放包括Aβ沉积主要发生在突触,而新加坡分子细胞生物学研究院发现APP只在中枢神经系统郎飞氏结簇集,在外周神经呈均匀分布,并提出了AD的郎飞氏结Aβ假说,认为郎飞氏结是Aβ的重要释放位点。