AIM: To develop rAAV2 containing cDNA of GAD-Ig fusion gene [GAD-Ig fusion gene is constructed by inserting glutamic acid decarboxylase(GAD) into N-terminal of murine IgG3 heavy chain(Ig)], and to study whether rAAV2 mediated GAD-Ig fusion gene expression could induce specific tolerance in IDDM animal model-nonobese diabetic (NOD) mice.
目的: 构建重组真核表达载体pSNAV- GAD -Ig[GAD- Ig融合基因是由小鼠GAD(glutamicaciddecarboxylase)基因插入到小鼠IgG3重链(Ig)基因的N端而成的 ], 制备含GAD- Ig融合基因cDNA的重组缺陷型腺相关病毒 -2 (rAAV2- GAD -Ig), 并探讨rAAV2所介导的GAD- Ig是否能诱导I型糖尿病(IDDM)动物模型 NOD(nonobesediabetic)小鼠产生特异性免疫耐受。
Studies on immune tolerance induced by the mixed infusion of mesenchymal stem cells and bone marrow cells after islet transplantation;
间充质干细胞联合骨髓细胞输注诱导胰岛移植免疫耐受的研究
Study on donor antigenic specificity CD4~+CD25~+Treg cells inducing allograft immune tolerance in rats;
应用CD4~+CD25~+Treg细胞诱导大鼠肾移植免疫耐受的研究
Progression of placenta in pregnant immune tolerance;
胎盘在妊娠免疫耐受作用中的研究进展
Comparison of effects of Tju103 and CTLA4-Ig on induction of tolerance of T lymphocytes;
Tju103和CTLA4-Ig诱导T淋巴细胞免疫耐受的比较(英文)
Posttransplant Administration of Allogeneic Bone Marrow Transfusion Combined with FK506、MMF and Anti-CD28mAb Induces Rat Hepatic Allograft Tolerance;
免疫抑制剂联合供体骨髓输注诱导大鼠肝移植免疫耐受的实验研究
To investigate the mechanism of tolerance of organ transplantation following syngenic hematopoietic stem cell transplantation(HSCT),the mouse model was constructed by allogenic skin transplantation,and FK506 was injected into peritoneal cavity 2 weeks later.
为了研究同基因造血干细胞移植诱导器官移植免疫耐受的可行性。
Unresponsiveness to an antigen that normally produces an immunological reaction.
免疫耐受性对一般会产生免疫性反应的抗原不作任何反应
Roles and mechanism of tolerogenic dendritic cells in transplantation immunity
免疫耐受性树突状细胞在移植免疫中的作用及其分子机制
Induced Immune Tolerance for Therapy of EAU;
诱导免疫耐受治疗实验性自身免疫性葡萄膜炎
In contrast to immunologic tolerance, immunodepression is nonspecific.
与免疫耐受相反，免疫抑制是非特异性的。
Ovalbumin Immune Tolerance Factors Induce OVA Specific Peripheral Immune Tloerance in Na(?)ve Balb/C Mice
卵清蛋白免疫耐受因子免疫学活性的研究
The Research on Preparation and Immunoactivity of OVA Immune Tolerance Factor
OVA免疫耐受因子制备及其免疫活性研究
Ovalbumin immune tolerance factors induce OVA specific peripheral immune tolerance in naive BALB/c mice
卵清蛋白免疫耐受因子转移免疫耐受活性的研究
Role of a Novel C-type Lectin-like Inhibitory Receptor KLRL1 in Immune Tolerance and Its Related Mechanisms
新型免疫抑制性受体KLRL1在免疫耐受中的作用及其相关机制研究
Relationship between Hepatic Pathology and Cellular Immune Status of Patients with Chronic Hepatitis B Virus in Immune Tolerant Phase;
免疫耐受期慢性HBV感染者肝脏病理与细胞免疫状况关系的研究
Mechanisms of Immunotolerance Disorder in Mouse Model for Autoimmune Diabetes;
自身免疫性糖尿病模型鼠免疫耐受机制异常的研究
A Study on Intrahepatic Immune Competent Cells in Immune Tolerant Phase in Patients with Chronic Hepatitis B Virus Infection;
HBV慢性感染患者免疫耐受期肝组织免疫细胞的研究
Bone Marrow-derived Mesenchymal Stem Cells and Immunogenicity of the Role of Immune Tolerance Induced by the Clinical Application
骨髓间充质干细胞免疫原性及诱导免疫耐受作用的临床应用
Acceptance of a tissue graft or transplant without immunological rejection.
耐药性接受移植组织的而无任何免疫性的排斥
Study of Inducing Tolerogenic Dendritic Cells in Vitro and Immunologic Tolerance in Vivo;
耐受性树突状细胞体外培养和体内诱导免疫耐受的研究
Established the model by transfused tolerogenic dendritic cells in abdominal cavity to induce immunological tolerance in the mouse
腹腔输注耐受性树突状细胞诱导小鼠免疫耐受研究
Progress on the regulatory T cells and immune tolerance in organ transplantation
调节性T细胞与器官移植免疫耐受的研究进展
Relationship between Toll-like receptors and maternal-fetal immunotolerance
Toll样受体与母胎免疫耐受的关系
Research progress of immune tolerance induced by donor specific transfusion in renal transplantation
供者特异性输注诱导肾移植受者免疫耐受的研究进展