Presenilin 1 belongs to the family of intramembrane-cleaving protease, a kind of proteases that catalyse peptide bond hydrolysis within lipid bilayer membranes, although its unique transmembrane structure and catalytic mechanism are not revealed completely, the current impo.
PS1其独特的跨膜结构和催化机制虽然还未完全揭示,但近期相关的研究取得了重要成果:PS1有10个疏水区,跨膜9次,其N端位于胞内,C端位于胞膜外或者内质网腔内,亦或不同程度地插入膜内,2个起催化作用的天冬氨酸残基都位于疏水性的膜内,膜蛋白底物被催化水解时必须先结合到酶的疏水表面上来,然后再进入位于活性部位。
An aerodynamic force model which is expressed by shape coefficients was adopted,applying Newmark′s β-method together with Newton Raphson to nonlinear dynamic increment equilibrium equation under wind-loading to obtain a time domain method which was used for aerodynamic instability of large-span cable and membrane structures.
采用体型系数表达的空气动力模型 ,将Newmark β法和Newton Raphson法相结合应用于风荷载作用下的非线性动力增量平衡方程中 ,形成大跨索膜结构空气动力失稳分析的时程分析方法。
ANALYSIS OF THE TRANSMEMBRANE STRUCTURE OF THE RECEPTOR PROTEIN AgrC IN agr SYSTEM OF Staphylococcus aureus
金黄色葡萄球菌agr系统受体蛋白AgrC的跨膜结构分析
Verapamil Blocks HERG Channel by the Helix Residue Y652 and F656 in the S6 Transmembrane Domain;
维拉帕米作用于S6跨膜结构域的Y652和F656氨基酸残基阻断HERG离子通道
Quercetin Activates Wild Type hKv1.5 Channel Expressed in Xenopus Oocytes by a Residue I502 in S6 Transmembrane Domain;
槲皮素作用于S6跨膜结构域的I502氨基酸残基激活野生型hkv1.5离子通道
Block Effect of Capsaicin on the Human HERG Potassium Currents Was Enhanced by S6 Mutation at Y652
S6跨膜结构域的Y652氨基酸残基突变增强辣椒素阻断人类HERG钾通道的作用
Membrane-inserted Structures and Orientation of the Transmembrane Segments of Slc11a1
Slc11a1跨膜肽段的嵌膜结构和取向
Wind-induced response analysis of a large-span cable-membrane roof
大跨度索-膜屋盖结构风振响应分析
Dynamic coefficients of large-span cable-membrane roof structures
大跨度索膜屋盖结构的风振系数研究
Advances in the viral transmembrane proteins:structure,function and antiviral drug design
病毒跨膜蛋白的结构功能与抗病毒药物设计
COORDINATED FORM-FINDING ANALYSIS OF TENSIONED MEMBRANE STRUCTURES OF GIVEN CABLES' RATIO OF RISE TO SPAN
给定索矢跨比的张拉式膜结构协同形态分析
The topology prediction of transmembrane protein is a hot in Bioinformatics.
跨膜蛋白拓扑结构预测是生物信息学的研究热点之一。
Mechanism for Cellular Internalization and Aapplication of the TAT Protein Transduction Domain;
TAT蛋白转导结构域跨膜递送机理及其应用基础研究
The Study of the Transmembrane Activity of the PTD of Tat Protein Fused at the Carboxyl-terminus of Heterologous Protein;
融合在外源蛋白羧基端的Tat蛋白转导结构域的跨膜递送作用研究
The Research of the Localization of Target Protein with Transmembrane Domain as Multi-peptide Tag
以跨膜蛋白疏水结构域为多肽标签的目标蛋白酶定位研究
Site Installation Technology for Long-Span,Multiunit,and Continuous Cable-Membrane Structure of Shanghai World Expo Axis
世博轴大跨度多单元连续索膜结构现场安装施工技术
Design of Cable and Membrane Structures Awning and Analysis on Accident of Membrane Structure Projects;
索膜结构挑蓬设计及膜结构事故分析
Scheme Design of Large-span Steel Structure Truss Structure
大跨度空间钢结构桁架结构设计研究
STRUCTURAL DESIGN OF A MILL BUILDING WITH LONG-SPAN AND SUPERHIGH HEAVY-DUTY STEEL STRUCTURES
大跨度超高重型钢结构厂房结构设计
Structural Analysis on 250-m Large-span Continuous Rigid Frame Bridge
250m大跨度连续刚构桥的结构分析