Objective:To investigate the mechanism of hearing pathway NMDAR regulating the changes of phosphorylated c-Jun expression in spiral ganglion after exposed Kunming mice to neural injury noise stimulation to induce permanent or temporary threshold shift.
目的:通过神经损伤性噪声引起4周昆明小鼠出现暂时性阈移(TTS)和永久性阈移(PTS),探讨听觉通路N-甲基D-天冬氨酸受体(NMDAR)活性调节耳蜗螺旋神经节(CG)磷酸化c-Jun变化。
Method: Based on the statistics analysis of 103 guinea pigs temporary threshold shift(TTS),drawed frequency distribution graph of left and right TTS mean,investigated the regularity of distribution,decided the susceptible and unsusceptible noise-induced hearing loss guinea pigs with normal distribution method,study the rationality of this method.
方法:通过对103只豚鼠的暂时性听阈偏移值进行统计学分析,作左右耳暂时性听阈偏移均值频数分布图,探讨其分布规律;利用正态分布法评价噪声听觉损伤易感组与不易感组豚鼠,并探讨其合理性。
After launching, temporary threshold shifts for each frequency were lower than.
结果 :射手位置脉冲噪声的峰值声压级在15 7～ 16 4dB之间 ,发射后受试者两耳各频率的暂时性听阈偏移均小于 5dB ,血压稳定 ,心电图、一般耳科检查未见异常 ,1名受试者心率无变化 ,另 1名受试者发射后即刻心率明显增加。
Aim: To observe the combined effects of four physical factors(noise, lighting, temperature and humidity) on temporary threshold shift (TTS).
目的 :观察舰艇舱室环境噪声、照明、温度、湿度 4种物理因素联合作用对暂时性听阈偏移的影响。