Generalized myalgia,ostalgia and arthralgia attributed to dasatinib
达沙替尼致全身肌肉骨骼关节疼痛
Study on synthetic process of dasatinib
达沙替尼的合成工艺研究
The chloro groups of 4,6-dichloro-2-methylpyrimidine were successively substituted with amino group of 5,and N-hydroxyethylpiperazine to give antitumor agent dasatinib monohydrate in 52%overall yield.
最后4,6-二氯-2-甲基嘧啶先与5进行亲核取代反应,再与N-羟乙基哌嗪发生亲核取代反应制得抗肿瘤药达沙替尼—水合物,总收率约52%。