Pyruvate decarboxylase and it′s applications in chiral synthesis;
丙酮酸脱羧酶及其在手性合成中的应用
The synthesis of chiral pharmaceuticals is a hot issue of the development in pharmaceutical in the world,asymmetric hydrogenization of which is the successful technology in the chiral synthesis.
手性药物的合成是目前全球药物开发研究的热点,而不对称氢化是手性合成中最成熟的技术。
The background,status and prospective for the rapid advancement of biocatalysis technology in recent years are described,and its wide application in the field of chiral synthesis is highlighted.
本文概述了生物催化技术近年来迅速发展的背景、现状和前景,特别谈到酶在手性合成领域的广泛应用;结合国内外实例,分别介绍了生物催化的不对称氧化还原反应和水解酶催化的对映选择性合成两个主要方面的研究与开发动态。