The key intermediate 3-methylaminopiperidine was synthesized from 3-bromopyridine with catalyst via ammonolysis and hydrogenization.
以3-溴吡啶为原料,在催化剂作用下经氨解、加氢还原制备关键中间体3-甲胺基哌啶,并考察加氢过程中催化剂类型和反应温度的影响,再以甲氧环合酯(1-环丙基-6,7-二氟-8-甲氧基-1,4二氢-4-氧代喹啉-3-羧酸乙酯)为起始物,在乙酐中与硼酸螯合,并与3-甲胺基哌啶缩合,最后水解制备巴洛沙星。
The Reactivity of the Bromine of 2-Bromopyridine in the Reaction with Sodium Alcoholates
溴吡啶的溴原子被烷氧基取代的化学活性
Pyridinium Hydrobromide Perbromide Catalyzed Organic Reaction under Green Condition
绿色条件下三溴吡啶催化有机反应的研究
Study on Color Reaction of Ruthenium with 5-Br-PADAP;
试剂5-(溴吡啶偶氮)-5-二乙氨基酚与钌(Ⅲ)的显色反应研究
Study on the Color Reaction of Palladium with 3,5-dibromopyridinglazo 5 methoxyphenol;
3,5-二溴吡啶偶氮对甲氧基酚与钯(Ⅱ)的显色反应研究
Synthesis of 3-Bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic Acid
3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸的合成
cetylpyridinium bromide precipitation
鲸蜡基溴化吡啶鎓沉淀法，十六烷基溴化吡啶鎓沉淀法[纯化寡核苷酸的一种方法]
The Crystal Structure of 3,5-di-Br-PADAT
5-[(3,5-二溴-2-吡啶)偶氮]-2,4-二氨基甲苯的晶体结构
Conductivity Behavior of Microemulsion System of Hexadecylpyridine Bromide
溴代十六烷基吡啶微乳液体系的电导行为研究
Study on Synthesis of 2-Bromo-4-aminopyridine
农药中间体2-溴-4-氨基吡啶的合成研究
Fading Spectrophotometric Method for the Determination of Cetylpyridinium Bromide with Azo Blue
偶氮蓝褪色光度法测定溴代十六烷基吡啶
Study on the chromogenic reaction of the system Samarium (III) DBS-chlorophosphonazo-hexadecylpyridinium bromide-ethanol;
二溴磺酸偶氮氯磷-溴代十六烷基吡啶-钐-乙醇显色体系的分析研究
Separation of Platinum(Ⅳ) by Floatation with the Reaction System of Cetylpyridine Bromide-Potassium Bromide-Sodium Nitrate
溴化十六烷基吡啶-溴化钾-硝酸钠体系浮选分离铂
Determination of Crystal Structure of 5-Br-PADAT
5—(5—溴—2—吡啶偶氮)—2,4—二氨基甲苯的晶体结构测定
Extraction of fucoidan-galactosan sulfate from Laminaria jap onica with cetylpyridinium bromide
溴代十六烷基吡啶法提取海带岩藻半乳聚糖硫酸酯
Spectrophotometric Determination of Micro Amounts of Nickel With 2-[2-(3,5-Dibromopyridyl)Azo)-5-Di-ethylaminobenzoic Acid
2-〔(3,5-二溴-2-吡啶)偶氮〕-5-二乙氨基苯甲酸分光光度法测定微量镍
Spectrophotometric determination of Cr (Ⅵ) with 5-Br-PADAP in acid solution
用2-(5-溴-2-吡啶偶氮)-5-二乙氨基苯酚分光光度法测定铬(Ⅵ)
A Study on Colour Reaction of 3,5-Br-PADAP and Bismuth
2-(3.5-二溴-2-吡啶偶氮)-5-二乙氨基苯酚与铋的显色反应研究
Study of the Colour Reaction of Alu-minium(Ⅲ)ith 5’-Nitrosalicylfluoroneand Cetylpyridinium Bromide
铝－5＇－硝基水杨基荧光酮－溴化十六烷基吡啶显色反应的研究及应用