A new method for the preparation of fosphenytoin was discussed in this paper.
以抗癫痫药物苯妥英为原料,通过合成3-羟甲基-苯妥英、3-氯甲基-苯妥英、3-羟甲基-苯妥英磷酸二苄酯、3-羟甲基-苯妥英磷酸酯等4种中间产物,最终得到目标产物磷苯妥英,总收率35。
OBJECTIVE To develop a simple reversed-phase high-performance liquid chromatography(HPLC) method for thesimultaneous determination of the antiepileptic drugs(AEDs) phenytoin(PHT),its prodrug fosphenytoin(FOS),and its metabolite 4′-hydroxyphenytoin(4′-HPPH) in human plasma.
目的建立同时测定人血浆中抗癫痫药物磷苯妥英(FOS)、苯妥英(PHT)及其主要代谢产物4′-羟苯妥英(4′-HPPH)浓度的高效液相色谱法。
Determination of phenytoin sodium and schisandrin in Compound Valpromide Capsule by HPLC;
HPLC测定复方丙戊酰胺胶囊中苯妥英钠和五味子醇甲的含量
Pharmaceutical care of severe toxicosis of phenytoin sodium;
重度苯妥英钠中毒的药学监护
Damage of Ileum in Experimental Peritonitis in mice and Effect of Phenytoin Sodium Intervention;
小鼠实验性腹膜炎回肠组织损伤性变化以及苯妥英钠干预的影响
Simultaneous determination of phenobarbitone,phenytoin and carbamazepine in human plasma by RP-HPLC;
RP-HPLC同时测定苯巴比妥、苯妥英和卡马西平的血药浓度(英文)
Simultaneous separation and determination of zonisamide,phenytoin carbamazepine and carbamazepine 10,11-epoxide in human plasma using isocratic reversed-phase HPLC;
高效液相色谱法同时测定人血浆中唑尼沙胺、苯妥英、卡马西平及环氧卡马西平的浓度
Clinical research on withdrawal and replacement of phenytoin and phenobarbitone in epileptic patients
癫痫病人撤换苯妥英钠和苯巴比妥的临床研究
The Study of Pheytoin Sodium on Penetration Across the Rat Skin and Gels;
苯妥英钠经皮渗透性及凝胶剂的研究
Development of Phenytoin Poly (Lactide-co-glycolide) Microspheres;
苯妥英钠聚乳酸—羟基乙酸微球的研制
Toxicokinetics of Phenytoin after Intravenous Injection Administration to Rats
大鼠静注苯妥英钠的毒代动力学研究
Research advances in the mechanism of phenytoin-induced gingival overgrowth
苯妥英钠致牙龈增生机制的研究进展
Determination of carbamazepine、phenytoin、phenobarbital In human serum concentration by HPLC with single step collection
单步萃取-HPLC法同时测定人血清中卡马西平、苯妥英钠、苯巴比妥浓度
Influence of Dilantin on serum immunosuppressive factor in burn patients
苯妥英钠对烧伤患者血清免疫抑制因子的影响
THE OBSERVATION OF NEUROELECTROPHYSIOLOGY OF PATIENTS WITH EPILEPSY IN LONG-TERM TAKING DILANTIN
长期服用苯妥英钠的癫?患者神经电生理观察
Experimental Study of the Effects of Phenytoin Sodium on the Survival of Random Pattern Skin Flaps;
苯妥英钠对随意皮瓣成活影响的实验研究
Studies on Toxicokinetics of Phenytoin Sodium in Rats
苯妥英钠在大鼠体内的毒代动力学研究
Comparison of Dissolution of Phenytoin Sodium Tablets from Different Pharmaceutical Companies in Vitro
不同厂家苯妥英钠片的体外溶出度比较
Photometric Determination of Sodium Phenytoin by Its Charge Transfer Reaction with Alizarin Red
基于与茜素红的荷移反应光度法测定苯妥英钠
SIMULTANEOUS DETERMINATION OF THE CONCENTRATION OF PHENYTOIN AND PHENOBARBITAL IN NORMAL HUMAN PLASMA BY HIGH-PRESSURE LIQUID CHROMATOGRAPHY
应用高压液相色谱分析法同时微量测定人血浆中苯妥英钠和苯巴比妥的浓度
Objective To find out the best and effective serum concentration of DPH for patients with epilepsy.
①目的探讨癫痫病人应用苯妥英钠(PH)疗的最佳有效血药浓度。
an anticonvulsant drug (trade name Dilantin) used to treat epilepsy and that is not a sedative.
一种用来治疗癫痫症的非止痛的抗抽搐的药物（商标是苯妥英钠）。
Objective To investigate the affect of Dilantin on the immunosuppressive factor in serum of the burns patients.
目的 研究苯妥英钠对烧伤患者血清免疫抑制因子的影响。
Clinical significance of serum and saliva levels of dilantin in epilepsy
癫痫病人血、唾液的苯妥英钠浓度监测的临床意义
Clinical Observation and Study of Salivary DPH Levels Monitoried by Fluorescence Polarization Immuno Assay
荧光偏振免疫法测定唾液苯妥英钠质量浓度的临床研究