Apurinc/apyrimidinic endonuclease 1/redoxfactor 1 is a functional complexity of a biological macromolecule,with both endonuclease activation for apurinc/apyrimidinic sites and mediating ability of transcription factor.
脱嘌呤/脱嘧啶核酸内切酶1(APE1)是一个生物大分子功能复合体,既具有脱嘌呤/脱嘧啶位点(AP位点)核酸内切酶活性,又具调节转录因子的活性。
AIM:To investigate the correlation between p53 and apurinic/apyrimidinic endonuclease 1(APE1)gene expressions in epithelial ovarian carcinoma and their roles in the chemoresistance of ovarian carcinoma.
目的:探讨脱嘌呤/脱嘧啶核酸内切酶(APE1)基因和P53在卵巢上皮性癌中的表达相关性,探讨两者与卵巢癌化疗耐药的相关性。
Objective To construct DNA damage and repair gene apurinic/apyrimidinic endonuclease (APE1) siRNA expression vector pSilence APE1 and investigate its inhibitory effect on the expression of APE1 in osteosarcoma cell HOS and 9901 in vitro.
目的构建DNA损伤修复基因脱嘌呤/脱嘧啶核酸内切酶APE1siRNA表达载体pSilenceAPE1,观察其对骨肉瘤细胞HOS和9901APE1蛋白表达的抑制作用。
Objective To explore the relation between changes in apurinic/apyrimidinic endonuclease (APE1) gene expression and effects of melphalan on multiple myeloma (MM) cells.
目的探讨脱嘌呤/脱嘧啶核酸内切酶(APE1)基因在多发性骨髓瘤(multiplemyeloma,MM)细胞中的表达变化及其与马法兰作用的关系。
Objective To investigate the role of apurimidinic endonuclease 1(APE1)in the carcinogenesis and progression of colorectal carcinoma(CRC).
目的探讨DNA修复基因脱嘌呤/脱嘧啶核酸内切酶(apurinic/apyrimidinic endonuclease 1,APE1)在大肠癌发生、发展中的作用。
Objective To explore the relationship between genetic polymorphisms in apurinic/apyrimidinic endonuelease(APE1)and ADP ribosyltransferase(ADPRT) and individuals susceptibility to chronic benzene poi- son ing(BP).
目的探讨脱嘌呤/脱嘧啶核酸内切酶(APEl)和腺苷酸二磷酸核糖基转移酶(APDRT)的基因多态与慢性苯中毒易感性的关系。
Study on significance of single nucleotide polymorphisms in the redox domain of aprimidinic/apurinic endonuclease/redox factor-1 gene in Chinese sporadic colorectal cancer;
脱嘌呤/嘧啶核酸内切酶基因氧化还原功能区单核苷酸多态性在散发性大肠癌中存在意义的探讨