Influence of okadaic acid on apoptosis of Balb/c 3T3 cells during the tumor promotion stage;
岗田酸促癌作用过程中对Balb/c 3T3细胞凋亡的影响
Objective To explore the changes of osteopontin (OPN) gene expression induced by tumor promoter of 12-O-tetradecanoylphorbol13-acetate(TPA),okadaic acid(OA) or cadmium chloride(CdCl_(2)).
目的探讨促癌物佛波酯(12-O-tetradecanoylphorbol-13-acetate,TPA),岗田酸(okadaic ac id,OA)和氯化镉(cadm ium chloride,CdC l2)在促进BALB/c 3T3细胞转化过程中对骨桥素基因(OPN)转录表达的影响。
To study the effect of protein phosphatase (PP) on functions of cholinergic neuron, a selective inhibitor of PP, okadaic acid (OA) was injected into the Meynert nucleus basalis of rats.
将PP抑制剂岗田酸 (okadaicacid ,OA)注入大鼠双侧Meynert基底核 ,并经免疫印迹检测τ(tau)蛋白磷酸化程度、经微渗透结合HLPC检测Ach、经Morris水迷宫检测大鼠的空间记忆能力 。