RNA interference(RNAi) refers to the process where by double-stranded RNA(dsRNA) induces sequence-specific post-transcriptional gene silencing(PTGS).
RNA干扰(RNA i)是由双链RNA(doub le-stranded RNA,dsRNA)介导的、序列特异的转录后基因沉默机制,是一古老的细胞反应通路,其在抵抗病毒感染、抑制转座子活动、调控内源性基因表达等方面发挥重要作用。
RNAi is a mechanism of post-transcriptional gene silencing (PTGS) initiated by the introduction of double-stranded RNA(dsRNA) and can be used as a powerful tool to knock out the expression of specific genes in a variety of organisms.
RNA干涉(RNA interference,RNA1)是由双链RNA导入而引起的转录后基因沉默,它可以作为一种有力的工具在多种有机体中抑制特异性基因的表达。
Gene silencing is the main factor of transgene inactivity?There are two kinds of gene silencing,tran-scriptional gene silencing and post-transcriptional gene silencing.
一种是由于DNA甲基化、异染色质化以及位置效应等引起的转录水平上的基因沉默 ;另一种是转录后基因沉默 ,有活跃的启动子 ,能转录外源基因 ,核内有正常水平的mRNA ,细胞质不积累mRNA。
Post-transcriptional Gene Silencing(PTGS) and Its Application to Crop Genetic Improvement;
转录后基因沉默(PTGS)及其在作物遗传改良中的应用
Posttranscriptional gene silencing(PTGS) is considered to be one of dominant mechanisms of RNA-mediated resistance.
转录后基因沉默现象是植物抵御病毒入侵、保持自身基因组完整性的一种防御机制。
Virus Inhibitory Protein of Post Transcriptional Gene Silencing and Its Inhibitory Mechanism;
抑制转录后基因沉默的病毒蛋白及其抑制机制
Homology dependent gene silencing (HdGS),which is the generic term for transcriptional gene silencing (TGS),post transcriptional gene silencing (PTGS) and RNA mediated virus resistance (RmVR) have been shown to frequently occur in transgenic plants.
基因沉默研究中所发现的转录后基因沉默现象是植物抵御病毒入侵、保持自身基因组完整性的一种防御机制 ,是植物与病毒共进化的结果。
Since transgene silencing was found in transgenic plants,many scholars have studied it extensively and considered that it has three functional mechanisms:post dependent gene silencing,transcriptional gene silencing,post transcriptional gene silencing.
本文对转基因植物转录后基因沉默的特点、机理及应用方面的进展作了综
Virus Inhibitory Protein of Post Transcriptional Gene Silencing and Its Inhibitory Mechanism;
抑制转录后基因沉默的病毒蛋白及其抑制机制
Application Study on Post-transcriptional Gene Silencing in Tobacco Resistance to PVY and CMV;
转录后基因沉默在烟草对PVY和CMV双价抗性中的应用研究
Study on Control Plant Cucumber Mosaic Virus Through Post-transcriptional Gene Silencing Approach;
利用转录后基因沉默（PTGS）防治作物黄瓜花叶病毒病
Homology-dependent gene silencing (HdGS), which is the generic term for transcriptional gene silencing (TGS), post-transcriptional gene silencing (PTGS) and RNAmediated virus-resistance (RmVR) have been shown to frequently occur in transgenic plants.
其中，同源依赖的基因沉默又可以分为转录水平的基因沉默和转录后水平的基因沉默。
Silencing LRP1B with huge transcript by RNAi method
应用RNAi技术沉默大转录本基因LRP1B
The Influence of SelW on GSH and GPx after Post-Transcriptional Gene Silencing in Mouse Skeletal Muscle Cell
SelW基因转录后沉默对小鼠骨骼肌细胞内GSH及GPx影响研究
Study on Knock-down the Expression of Mouse Znf313 Gene by Small Interfering RNA and the Transcriptional Regulation of Human ZNF313 Gene;
小干扰RNA对小鼠Znf313基因的沉默作用及人ZNF313基因的转录调控研究
Gene silencing is a kind of epigenetic phenomenon discovered in transgenic plants in recent years.
基因沉默是近几年来在转基因植物中发现的一种后生遗传现象。
Distribution of HPV Genotypes in the Patients with Cervical Carcinoma and Its Precursors and Transcriptional Gene Silencing of HPV 16 Oncogenes;
宫颈癌及其前期病变HPV感染与基因型分布及HPV16癌基因转录水平沉默的研究
Inheritance of Transgenic Silence of HMW-GS Genes in Hybrids and Backcrosses of Wheat
小麦HMW-GS转基因沉默效应的遗传分析
Analysis the Mechanism of Antisense Transgene Mediated Gene Silencing;
反义转基因介导的基因沉默机制的研究（分析）
Inheritance and Expression of Silenced HMW-GS Genes in Wheat
转基因小麦沉默的HMW-GS基因的遗传及表达
Inhibiting Metastasis of Pancreatic Cancer Cells Silenced by siRNA KAI1 Gene;
KAI1基因siRNA沉默对胰腺癌细胞转移作用的研究
The Research of HIF-1α Silence by siRNA Reversing the Resistance of Ovarian Cancer;
siRNA沉默HIF-1α基因逆转卵巢癌耐药的实验研究
Akt1 Silencing Inhibits Lung Metastasis of Murine Breast Cancer Cells
Akt1基因沉默降低小鼠乳腺癌细胞的肺转移能力
Post-transcriptional Processing of Two Functions of Unknown Transcription Factor Genes in Zea mays
玉米两个功能未知转录因子基因的转录后加工
Morphology of Myoblasts with MSTN Gene Silencing
肌母细胞MSTN基因沉默后的细胞形态学观察
Differential proteomic analysis of goldfish embryos after silencing the Vsx1 gene
沉默Vsx1基因后金鱼胚胎的差异蛋白质组学研究