PJ was treated with di-tert-butyl dicarbonate in the presence of K2CO3 to give N-Boc-1H-pyrazole-1-carboxamidine(PB),then PB reacted with di-tert-butyl dicarbonate in the presence of 4-dimethylaminopyridine to give N,N,N′-tri-Boc-1H-pyrazole-1-carboxamidine(PT),PT reacted with Mg(ClO4)·6H2O to give N,N -di-Boc-1H-pyrazole-1-carboxamidine(PM).
1H-吡唑-1-甲脒盐酸盐在碳酸钾存在下和二碳酸二叔丁酯反应制备了N-叔丁氧基羰基-1H-吡唑-1-甲脒(PB),PB和二碳酸二叔丁酯在4-二甲氨基吡啶的催化下反应制备了N,N,N′-三叔丁氧基羰基-1H-吡唑-1-甲脒(PT),PT和高氯酸镁六水合物反应制备了标题化合物。